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The proliferation of the osteosarcoma cells was inhibited by treatment of LAS02 which was clearly demonstrated by MTT assay result. At dosage of 100 and 200 µg/ml dosages 34.02% and 42.21% inhibition was seen (as shown in Graph (i)) which was found to be more than the inhibition shown by the positive control or Imatinib the modern drug of oncology. The IC50 (Inhibitory Concentration) was attained near the dosage of 300µg/ml. The dosages more than 500 µg/ml were found exceeding toxicity levels.
The purpose of this study was to evaluate the acute oral toxicity study of LAS02 in female Sprague Dawley rat model. [...]
The purpose of this study was to evaluate the maximum tolerated dose of LAS02 in Sprague dawley female rat. [...]
The aim of this study was to evaluate the maximum tolerated dose of LAS02 in female Sprague Dawley rat. [...]